CDH8 polyclonal antibody
产品名称： CDH8 polyclonal antibody
英文名称： CDH8 polyclonal antibody
产品编号： PAB2476
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CDH8.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CDH8.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Expression of cadherin-8 in renal cell carcinoma and fetal kidney.
Blaschke S, Mueller CA, Markovic-Lipkovski J, Puch S, Miosge N, Becker V, Mueller GA, Klein G.Int J Cancer. 2002 Oct 1;101(4):327-34.
- 2.
- Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M.Biochem J. 2000 Jul 1;349(Pt 1):159-67.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of CDH8 (arrow) using rabbit CDH8 polyclonal antibody (Cat # PAB2476). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDH8 gene (Lane 2) (Origene Technologies).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast carcinomareacted with CDH8 polyclonal antibody (Cat # PAB2476), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 1006
- Protein Accession#:
- NP_001787;P55286
- Gene Name:
- CDH8
- Gene Alias:
- Nbla04261
- Gene Description:
- cadherin 8, type 2
- Omim ID:
- 603008
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq
- Other Designations:
- cadherin-8,putative protein product of Nbla04261
- Related Disease