Anti-SH2D1A Polyclonal Antibody

商品货号：	商品品牌：	规格	基本售价：	选择规格
K002236P-50ul	solarbio	50ul	960.00元
K002236P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-SH2D1A Polyclonal Antibody
别名	DSHP;EBVS;IMD5;LYP;MTCP1;SAP;SAP/SH2D1A;XLP;XLPD;XLPD1
应用	WB IHC
稀释比例	WB 1:500-2000. IHC 1:50-200.
交叉反应	Human Mouse Rat
蛋白分子量	14kDa
Gene ID	4068
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human SH2D1A
性状	液体
Public Immunogen Range	Recombinant protein of human SH2D1A
Subcellular Locations	Cytoplasm
Swiss Prot	O60880
克隆类型	Polyclonal Antibody
背景资料	This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.