Anti-CDK5(N-term) Monoclonal Antibody

品牌：solarbio | 货号：K001394M

商品货号：	商品品牌：	规格	基本售价：	选择规格
K001394M-50ul	solarbio	50ul	960.00元
K001394M-100ul	solarbio	100ul	1600.00元

英文名称 Anti-CDK5(N-term) Monoclonal Antibody
别名 LIS7;PSSALRE
应用 WB ICC
稀释比例 WB 1:500. IHC 1:150.
交叉反应 Human Mouse Rat Monkey
蛋白分子量 36kDa
Gene ID 1020
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG1
免疫原 Purified recombinant human CDK5(N-terminus) protein fragments expressed in E.coli.
性状 液体
Public Immunogen Range Purified recombinant human CDK5(N-terminus) protein fragments expressed in E.coli.
Subcellular Locations Cell junction Cell membrane Cell projection Cytoplasm Nucleus Perikaryon Peripheral membrane protein growth cone lamellipodium postsynaptic cell membrane postsynaptic density synapse
Swiss Prot Q00535
克隆号 2E8-F9-B7-C11
克隆类型 Monoclonal Antibody
背景资料 Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases, including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability. Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic strategies that block Cdk activity are unlikely to selectively target tumor cells.

英文名称	Anti-CDK5(N-term) Monoclonal Antibody
别名	LIS7;PSSALRE
应用	WB ICC
稀释比例	WB 1:500. IHC 1:150.
交叉反应	Human Mouse Rat Monkey
蛋白分子量	36kDa
Gene ID	1020
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG1
免疫原	Purified recombinant human CDK5(N-terminus) protein fragments expressed in E.coli.
性状	液体
Public Immunogen Range	Purified recombinant human CDK5(N-terminus) protein fragments expressed in E.coli.
Subcellular Locations	Cell junction Cell membrane Cell projection Cytoplasm Nucleus Perikaryon Peripheral membrane protein growth cone lamellipodium postsynaptic cell membrane postsynaptic density synapse
Swiss Prot	Q00535
克隆号	2E8-F9-B7-C11
克隆类型	Monoclonal Antibody
背景资料	Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases, including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability. Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic strategies that block Cdk activity are unlikely to selectively target tumor cells.