Anti-UGT1A1 Polyclonal Antibody

品牌：solarbio | 货号：K002762P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K002762P-50ul	solarbio	50ul	960.00元
K002762P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-UGT1A1 Polyclonal Antibody
别名	BILIQTL1;GNT1;HUG-BR1;UDPGT;UDPGT 1-1;UGT1;UGT1A
应用	WB
稀释比例	WB 1:500-2000.
交叉反应	Human Mouse Rat
蛋白分子量	60kDa
Gene ID	54658
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human UGT1A1
性状	液体
Public Immunogen Range	Recombinant protein of human UGT1A1
Subcellular Locations	Endoplasmic reticulum Endoplasmic reticulum membrane Microsome Single-pass membrane protein
Swiss Prot	P22309
克隆类型	Polyclonal Antibody
背景资料	This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.